Strain Data Sheet


Strain Information

BRC No.RBRC00113
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameC3H/HeSn-Ttf/+tf
Former Common nameC3H/HeSn-Ttf/+tf
H-2 Haplotype
ES Cell line
Background strainC3H
Appearanceagouti, tail defects, tufted (A/A, T tf/+tf)
agouti, tufted (A/A, + tf/+tf)
Strain developmentC3H/HeSn-Ttf/+tf strain was introduced to National Institute of Genetics from the Jackson laboratory in 1985.
Strain descriptionT, Brachyury, semidominant, Chr 17. Discovered in a laboratory stock. T/T homozygous embryos die at 10 days of gestation due to failure to form a normal mesoderm. T/+ heterozygote have a shortened tail and abnormal sacral vertebrae. T/t mice are tailless. tf/tf homozygous mice show repeated waves of hair loss and regrowth. tf gene is linked to the T/t complex.
Colony maintenanceSister-brother matingHeterozygote x Wild (tail defects x normal tail)

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Itpr3inositol 1,4,5-triphosphate receptor 317Itpr3<tf>tufted

Ordering Information

Donor DNA
Research applicationDermatology Research
Developmental Biology Research
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorToshihiko Shiroishi (National Institute of Genetics)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

Hatakeyama Y, Saito N, Mii Y, Takada R, Shinozuka T, Takemoto T, Naoki H, Takada S.
Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis.
Nat Commun 14(1) 1924(2023) 37024462