Strain Data Sheet


Strain Information

BRC No.RBRC00052
TypeWild-derived Inbred and Spontaneous Mutation
SpeciesMus musculus molossinus
Strain nameSHL
Former Common namehyperlipidemia
H-2 Haplotype
ES Cell line
Background strainKOR [Mus musculus molossinus]
Appearancewhite belly agouti
Strain developmentSpontaneous mutation arose in KOR wild-derived mouse colony. The mutant mice were maintained by sibling mating.
Strain descriptionSHL, spontaneously hyperlipidemia mutant mice. Spontaneous mutation arose in KOR mouse colony derived from Japanese wild-mice (Mus musculus molossius). Homozygous mutant mice show increased circulating cholesterol level. Homozygous mutant mice are viable and fertile (before onset of xanthoma). Females of homozygote show lower reproductive performance.
Colony maintenance
ReferencesMamm. Genome, 10, 352-357 (1999). 10087291
J. Atheroscler. Thromb., 8, 71-79 (2001). 11866033
The Lipid, 13, 318-324 (2002).

Health Report

Examination Date / Room / Rack2024/02/26Room:4-CRack:A


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Apoeapolipoprotein E7Apoe<shl>spontaneous hyperlipidemiaApoe

Ordering Information

Donor DNA
Research applicationCardiovascular Research
Hematological Research
Mouse Models for Human Disease
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.
DepositorYoshibumi Matsushima (Saitama Cancer Center)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
Strain AvailabilityCryopreserved embryos (within 1 month)
Live mouse (3 to 6 months)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

Genotyping protocol -PCR-
Mouse of the Month Jan 2006

BRC mice in Publications

No Data